Brain and Psychological factors in CPPS

The brain itself may be involved in causing CP/CPPS. Studies suggest that stress accompanied by depression and catastrophizing are potent factors in the development, prolongation, and perpetuation of CP/CPPS symptoms.

Brain psychological factors CPPS prostatitis

A resting state fMRI study of men with CP/CPPS found that the areas of brain activation during pelvic symptoms in men with CP/CPPS are different from other pain conditions. So a distinct set of neurological changes may accompany (or predispose to) CP/CPPS.

These psychosocial factors, such as catastrophizing and depression, have a significant effect on quality of life in men with CP/CPPS, but they can be treated using cognitive therapy.

CPPS and Catastrophizing

Catastrophizing is a term used by cognitive therapists to describe the anxious person’s tendency to anticipate extreme outcomes or to view unfortunate events as “catastrophic” and beyond their ability to cope. An example would be the traveler who thinks “If I miss my connecting flight, I don’t know what I’ll do!”

Catastrophizing in CP/CPPS found it to be associated with greater disability, depression, urinary symptoms, and pain. Catastrophizing with an element of helplessness is a very robust pain predictor and is linked to longer pain durations.


A depressed mood state increases a patient’s level of catastrophizing, impairs their emotion-regulation neurocircuitry, and amplifies their cortical responses to a noxious stimulus.

HPA axis

Depression and catastrophizing can also influence HPA axis responses. Studies have shown that HPA dysregulation may lead to abnormalities of inflammatory responses, resulting in chronic inflammatory and pain conditions such as interstitial cystitis or CP/CPPS. Men with CP/CPPS have a greater slope of the awakening cortisol response than do age-matched healthy controls, which suggests a dysfunctional HPA axis. Stress could also have an influence here. Several studies have shown an association between increased cortisol levels after awakening and psychological variables in chronically stressed individuals owing to work overload.

Further reading
Pain, Catastrophizing, and Depression in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Psychosocial variables affect the quality of life of men diagnosed with chronic prostatitis/chronic pelvic pain syndrome
Development of an evidence-based cognitive behavioral treatment program for men with chronic prostatitis/chronic pelvic pain syndrome.

Throw out the antibiotics and try these….


Q-Urol for prostatitis

Buy 1 get 1 FREE! Remember, use code 50UROL18. There is no better anti-prostatitis medication on the market, period. Q-UROL offers all of the benefits of Prosta-Q, but with time release technology and extra strength anti-inflammatory power. Published studies prove that both quercetin and pollen extract (also known as cernilton) calm CPPS symptoms. The combination is very effective for the majority of patients, and has been shown in published urological studies to help maintain prostate health and specifically target pelvic or genital discomfort.


BP-Qmax for prostatitis and BPH

Buy 1 get 1 FREE! Remember, use code 50QMAX19. BPH and Prostatitis share many symptoms. The proprietary blend of clinically proven all-natural ingredients found in BP-Qmax was developed in collaboration with leading urologists at major medical centers to assist men with prostate and urinary health issues and provide support for those seeking powerful, but natural, prostate health support. Contains optimum amounts of Beta-Sitosterol, Saw Palmetto, Flower Pollen and enzymes, as studied by academic urologists. Reduce nighttime urination and sleep through the night with BP-QMax™

TriverexMD and Trinoboost

trinoboost and triverex for libido repair

Buy 1 get 1 FREE! Remember, use code 30TRIN456. Trinoboost increases levels of nitric oxide (NO), vital for erections. TriverexMD contains Panax Ginseng, which has extensive clinical evidence (7 human clinical studies) proving effective for boosting male sexual health, especially erectile dysfunction. Try these natural remedies and avoid harmful ED drugs.


Multiright acide free vitamins

Buy 1 get 1 FREE! Remember, use code 2Multi3295. MultiRight is the only pH neutral, low acid multivitamin which means that it’s more bladder friendly than ever!  Most multivitamins are acidic (usually because of the cheap form of Vitamin C they contain) and can burn inflamed bladders, prostates and urethras. This product won’t do that. Kill the burn now!

New Product

New product

Your product here. Contact site management to advertise your product or medication to the pelvic pain community.


New Product

New product

Your product here. Contact site management to advertise your product or medication to the pelvic pain community.