A flavonoid that helps many prostatitis/CPPS patients
Quercetin is a plant-derived bioflavonoid with a wide range of effects. It is an anti-cancer agent, it affects the immune system, protects mast cells and even has an antimicrobial effect. It is also useful in treating musculoskeletal conditions.
Daniel Shoskes, prostatitis researcher, who discovered that quercetin could help many chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) patients, theorises that quercetin decreases inflammation and oxidant stress in the prostate while increasing local concentrations of beta-endorphins. He says that quercetin has also been shown to inhibit the induction and function of T cells in vitro, so it may be able to short-circuit the root cause of autoimmunity. Its general properties are: anti-oxidant, tyrosine kinase inhibitor, nitric oxide inhibitor, anti-inflammatory (inhibits NF-kB, blocks PGE-2 and cox-2 gene expression) and inhibitor of histamine and cytokine release from mast cells (quercetin inhibits the release of histamine, leukotrienes (LTs), prostaglandin D2 (PGD2), and granulocyte macrophage-colony stimulating factor (GM-CSF) from human cultured mast cells).
There have been numerous messages to our prostatitis forum by men heaping praise on this flavonoid, while a small proportion insist they have not been helped. Many of those not helped are taking cheap and unreliable brands of quercetin and aren’t getting the right dose (the most reliable brand is Prosta-Q). Dr Shoskes says that “Some patients notice improvement after the first few doses. For others it can take up to a month to work.” But like most medicines used to treat disease, quercetin does not help all sufferers because of genetic differences between people. This is the same for most drugs, which work for a percentage of people. However everyone with CP/CPPS should try it, because they may be one of the fortunate majority who are helped.
Some people like the idea that quercetin is having antibacterial effects (which studies have documented). But Dr Shoskes says “Quercetin MAY have effects on antibiotic resistant bacteria. I should emphasize that I have not found quercetin to be helpful clinically in my patients with documented infections.”