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Recent Key Research

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Biopsies Show Bacteria not Important

J Urol 2003; 169(2):584-588
Prostate Biopsy Culture Findings of Men With Chronic Pelvic Pain Syndrome do Not Differ From Those of Healthy Controls
Lee, Berger et al
...Bacteria cultured from transperineal prostatic biopsies do not differ between men with and without chronic pelvic pain syndrome. Prostatic bacteria obtained by biopsy are probably not etiologically related to the symptoms in the majority of men with chronic pelvic pain syndrome. More..


Bacterial Cultures not Useful

J Urol Sep 2002
Leukocyte And Bacteria Localization Comparisons In Men With Chronic Pelvic Pain Syndrome And Asymptomatic Men: A Case-Control Study
Nickel, Alexander, Schaeffer, Landis et al
.... Although men with chronic prostatitis routinely receive anti-inflammatory and antimicrobial therapy, we found that leukocytes and bacterial counts as we defined them do not correlate with severity of symptoms. These findings suggest that factors other than leukocytes and bacteria also contribute to symptoms associated with chronic pelvic pain syndrome.



Curr Opin Urol 2002 Jan;12(1):63-7
Understanding chronic pelvic pain syndrome
Bjerklund Johansen TE, Weidner W.
....New information from studies on the inflammatory response in expressed prostatic secretion in patients with chronic pelvic pain syndrome and in bladder tissue from patients with bladder pain syndrome/interstitial cystitis (BPS/IC) indicates that complex systems on the cytokine gene expression level may be operating in these diseases.....


Genetic Basis for chronic pelvic pain syndrome

Urology 2001 Aug;58(2):281
A case of familial clustering of bladder pain syndrome/interstitial cystitis (BPS/IC) and chronic pelvic pain syndrome

Dimitrakov JD.
A case of familial clustering of bladder pain syndrome/interstitial cystitis (BPS/IC) (BPS/IC) and chronic pelvic pain syndrome (CPPS), a symptom complex similar to IC that occurs in men, is reported. The proband was a 28-year-old woman with a 6-month history of severe frequency, urgency, and genital pain. After cystoscopy with hydrodistention and biopsy, a diagnosis of IC was made. IC was also diagnosed in the patient's mother and in two of her brothers, previously considered to have CPPS (category IIIB CPPS). A third brother was asymptomatic. This case highlights the importance of genetic factors in the onset of symptoms and natural history of IC and CPPS.


Potential Genetic Markers in CP/CPPS

This study is the first evidence of a genetic basis for CP/CPPS:
Biochim Biophys Acta 2002 Jan 2;1586(1):99-107
X Chromosomal short tandem repeat polymorphisms near the phosphoglycerate kinase gene in men with chronic prostatitis

Riley DE, Krieger JN.

.... observations suggest that Xq11-13 may contain one or more genetic loci that predispose toward CP/CPPS....


Mast Cell mediated prostatitis in Rats

J Urol. 2001 Jul;166(1):323-8.

Cell Relationship In A Wistar Rat Model Of Spontaneous Prostatitis

Keith IM, Jin J, Neal Jr D, Teunissen BD, Moon TD.

....While the correlation of the nerve mast cell axis with mast cell degranulation does not prove our hypothesis of mast cell mediated inflammatory mediator release in the development of nonbacterial prostatitis, it suggests that such a relationship is possible.


All CP/CPPS Inflammatory

This study hints that despite recent classifications of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) into inflammatory and non-inflammatory sub-categories, all CP/CPPS is in fact inflammatory:

Eur Urol 2001 Jan;39(1):72-78

Noninflammatory Chronic Pelvic Pain Syndrome: Immunological Study in Blood, Ejaculate and Prostate Tissue

John H, Barghorn A et al.
....Interleukin, complement and immunoglobulin determinations in serum and ejaculate reveal an inflammatory process even in Cat IIIB CP/CPPS. The findings of intra-acinar T-cell-rich infiltrates and the associated inflammatory reaction may be a significant advance in defining Cat IIIB CP/CPPS caused by a possible autoimmune component....

This study is supported by a December 2001 study by Berger, Kreiger et al.


Prostatic Inflammation not always CP/CPPS

Inflammation in the prostate does not necessarily mean you have chronic pelvic pain:
Eur Urol 2000 Apr;37(4):404-12
Inflammation in prostate biopsies of men without prostatic malignancy or clinical prostatitis. Correlation with total serum psa and psa density.
Schatteman PH, Hoekx L et al.
....Inflammation of the prostate is a histological finding in almost every set of prostate biopsies, even when there are no signs of clinical prostatitis....


Stress ups Bladder Mast Cells

Stress can physically change rat bladders, why not humans too?
The Journal Of Urology 2001;165:235-239
Role Of Afferent Neurons In Stress Induced Degenerative Changes Of The Bladder
Feriha Ercan; Sule Oktay; Nuray Erin
...Stress exposure led to pathological changes, including an increased number of mast cells, degenerated urothelium and dilated tight junctions, in the bladder.....


Normal Prostates Contain Bacteria

Bacteria are abnormal when found in your prostate and urethra, aren't they? But wait, it's not so simple. See the recent study called "Microbiologic Aerobic Studies On Normal Male Urethra" at the International Prostatitis Research Foundation website.