Recent Key Research
Biopsies Show Bacteria not Important
J Urol 2003; 169(2):584-588
Prostate Biopsy Culture Findings of Men With Chronic
Pelvic Pain Syndrome do Not Differ From Those of Healthy Controls
Lee, Berger et al
...Bacteria cultured from transperineal prostatic biopsies do not
differ between men with and without chronic pelvic pain syndrome.
Prostatic bacteria obtained by biopsy are probably not etiologically
related to the symptoms in the majority of men with chronic pelvic
pain syndrome. More..
Bacterial Cultures not Useful
J Urol Sep 2002
Leukocyte
And Bacteria Localization Comparisons In Men With Chronic Pelvic
Pain Syndrome And Asymptomatic Men: A Case-Control Study
Nickel, Alexander, Schaeffer, Landis et al
.... Although men with chronic prostatitis routinely receive
anti-inflammatory and antimicrobial therapy, we found that leukocytes
and bacterial counts as we defined them do not correlate with severity
of symptoms. These findings suggest that factors other than
leukocytes and bacteria also contribute to symptoms associated with
chronic pelvic pain syndrome.
CP/CPPS and IC
Curr Opin Urol 2002 Jan;12(1):63-7
Understanding
chronic pelvic pain syndrome
Bjerklund Johansen TE, Weidner W.
....New information from studies on the inflammatory response in
expressed prostatic secretion in patients with chronic pelvic pain
syndrome and in bladder tissue from patients with interstitial cystitis
indicates that complex systems on the cytokine gene expression level
may be operating in these diseases.....
Genetic Basis for chronic pelvic pain syndrome
Urology 2001 Aug;58(2):281
A
case of familial clustering of interstitial cystitis and chronic
pelvic pain syndrome
Dimitrakov JD.
A case of familial clustering of interstitial cystitis (IC) and
chronic pelvic pain syndrome (CPPS), a symptom complex similar to
IC that occurs in men, is reported. The proband was a 28-year-old
woman with a 6-month history of severe frequency, urgency, and genital
pain. After cystoscopy with hydrodistention and biopsy, a diagnosis
of IC was made. IC was also diagnosed in the patient's mother and
in two of her brothers, previously considered to have CPPS (category
IIIB CPPS). A third brother was asymptomatic. This case highlights
the importance of genetic factors in the onset of symptoms and natural
history of IC and CPPS.
Potential Genetic Markers in CP/CPPS
This study is the first evidence of a genetic
basis for CP/CPPS:
Biochim Biophys Acta 2002 Jan 2;1586(1):99-107
X
Chromosomal short tandem repeat polymorphisms near the phosphoglycerate
kinase gene in men with chronic prostatitis
Riley DE, Krieger JN.
.... observations suggest that Xq11-13 may contain one or more genetic loci that predispose toward CP/CPPS....
Mast Cell mediated prostatitis in Rats
J Urol. 2001 Jul;166(1):323-8.
Cell Relationship In A Wistar Rat Model Of Spontaneous Prostatitis
Keith IM, Jin J, Neal Jr D, Teunissen BD, Moon TD.
....While the correlation of the nerve mast cell axis with mast cell degranulation does not prove our hypothesis of mast cell mediated inflammatory mediator release in the development of nonbacterial prostatitis, it suggests that such a relationship is possible.
All CP/CPPS Inflammatory
This study hints that despite recent classifications of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) into inflammatory and non-inflammatory sub-categories, all CP/CPPS is in fact inflammatory:
Eur Urol 2001 Jan;39(1):72-78
John H, Barghorn A et al.
....Interleukin, complement and immunoglobulin determinations in
serum and ejaculate reveal an inflammatory process even in Cat IIIB
CP/CPPS. The findings of intra-acinar T-cell-rich infiltrates and
the associated inflammatory reaction may be a significant advance
in defining Cat IIIB CP/CPPS caused by a possible autoimmune component....
This study is supported by a December 2001 study by Berger, Kreiger et al.
Prostatic Inflammation not always CP/CPPS
Inflammation in the prostate does not necessarily
mean you have chronic pelvic pain:
Eur Urol 2000 Apr;37(4):404-12
Inflammation
in prostate biopsies of men without prostatic malignancy or clinical
prostatitis. Correlation with total serum psa and psa density.
Schatteman PH, Hoekx L et al.
....Inflammation of the prostate is a histological finding in almost
every set of prostate biopsies, even when there are no signs of
clinical prostatitis....
Stress ups Bladder Mast Cells
Stress can physically change rat bladders,
why not humans too?
The Journal Of Urology 2001;165:235-239
Role
Of Afferent Neurons In Stress Induced Degenerative Changes Of The
Bladder
Feriha Ercan; Sule Oktay; Nuray Erin
...Stress exposure led to pathological changes, including an increased
number of mast cells, degenerated urothelium and dilated tight junctions,
in the bladder.....
Normal Prostates Contain Bacteria
Bacteria are abnormal when found in your prostate and urethra, aren't they? But wait, it's not so simple. See the recent study called "Microbiologic Aerobic Studies On Normal Male Urethra" at the International Prostatitis Research Foundation website.