In the early 2000s, the concept of injecting the prostate transperineally with a combination of steroids (betamethasone) and antibiotics (to prevent the steroid-induced local immunosuppression leading to abscess) gained currency through the efforts of European practitioners, and especially Dr Federico Guercini of Rome, Italy. Dr Guercini claimed a high success rate (68% cured at 6 and 12 month follow-ups), and published an optimistic paper on the treatment in 2005.
Other researchers noted that there were some studies 20-30 years ago showing that the availability of antibiotics in the prostate following the intraprostatic protocol is exactly the same as the amount you get when you give the patient an intramuscular shot of the same antibiotic. The success rate in in these old trials was low and the complication rate was higher.
Dr J. Curtis Nickel, writing in his book “Textbook of Prostatitis” has this to say:
Intraprostatic injection of antibiotics
Intraprostatic injection into the caudal prostate was possibly first described in 1983 by Baert et al