CPPS and Genes
Several studies have linked chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and IC to specific genetic profiles
There are now several suggestive studies showing that a genetic basis for urologic pelvic pain conditions exist. There is an interesting twin study, a study showing that 30% of CPPS patients have a low IL-10 producing genotype (compared to 12% of controls), and studies on interstitial cystitis indicate that complex systems on the cytokine gene expression level may be operating in these diseases. Another interesting finding is that patients who fail therapy with Prosta-Q have a low TNF-alpha gene and a significantly lower proportion have a low IL-10 gene.
Despite all this, however, the precise importance of genetic susceptibility remains unclear.