CPPS and Genes

Several studies have linked chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and IC to specific genetic profiles

There are now several suggestive studies showing that a genetic basis for urologic pelvic pain conditions exist. There is an interesting twin study, a study showing that 30% of CPPS patients have a  low IL-10 producing genotype (compared to 12% of controls), and studies on interstitial cystitis indicate that complex systems on the cytokine gene expression level may be operating in these diseases. Another interesting finding is that patients who fail therapy with Prosta-Q have a low TNF-alpha gene and a significantly lower proportion have a low IL-10 gene.

Despite all this, however, the precise importance of genetic susceptibility remains unclear.

Biochim Biophys Acta 2002 Jan 2;1586(1):99-107

X Chromosomal short tandem repeat polymorphisms near the phosphoglycerate kinase gene in men with chronic prostatitis.

Riley DE, Krieger JN.

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) causes substantial morbidity afflicting approximately 10% of adult males. Treatment is often empirical and ineffective since the etiology is unknown. Other prostate and genitourinary diseases have genetic components suggesting that CP/CPPS may also be influenced by genetic predisposition. We recently reported a highly polymorphic short tandem repeat (STR) locus near the phosphoglycerate kinase gene within Xq11-13. Because this STR is in a region known to predispose towards other prostate diseases, we compared STR polymorphisms in 120 CP/CPPS patients and 300 control blood donors. Nine distinct allele sizes were detected, ranging from 8 to 15 repeats of the tetrameric STR plus a mutant allele (9.5) with a six base deletion in the flanking DNA sequence. The overall allele size distribution in the CP/CPPS patients differed from controls (Chi-square=19.252, df=8, P=0.0231). Frequencies of two specific alleles, 9.5 and 15, differed significantly in CP/CPPS vs. control subjects and allele 10 differed with marginal significance. Alleles 9.5 and 10 were both more common in CP/CPPS patients than controls while allele 15 was less common. These observations suggest that Xq11-13 may contain one or more genetic loci that predispose toward CP/CPPS. Further investigations involving family studies, larger patient populations, and other control groups may help elucidate this potential genetic predisposition in CP/CPPS.

Vulvar Pain

There is a precedence in women. Vulvar vestibulitis, inflammation of small glands in the vagina, the most common cause of painful intercourse in young women, is associated in about half the cases with a rare form of a gene that regulates inflammation (the interleukin-1 receptor antagonist gene), research shows. When an inflammatory response is triggered by any means, women with this form of the gene have difficulty ending the response, even after the initial stimulus is gone with the result being chronic prolonged inflammation and pain.

E. coli Infection can induce chronic pelvic pain

A 2011 study theorised that a particularly virulent strain of E. coli can start a pelvic pain condition in some men with a particular genetic predisposition. The pain condition persists even after the bacterial infection ends.