AUA 2010 - Colon inflammation affects bladder muscle

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AUA 2010 - Colon inflammation affects bladder muscle

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AUA 2010 - Diminished detrusor muscle contractility underlies the urinary bladder dysfunction induced by experimental colitis: Mechanism for pelvic organ cross-talk

Thursday, 10 June 2010

SAN FRANCISCO, CA USA (UroToday.com) - Chronic pelvic pain is a common and potentially devastating condition. Previous reports have established a viscero-visceral cross-sensitivity between the genitourinary and gastrointestinal systems as well as a role of TRPV1 in the development of neurogenic inflammation in the pelvis. Further to her work presented previously that demonstrated an increase in bladder inflammatory neuropeptides and changes in the expression of the sodium channels in the bladder dorsal root ganglia in patients with acute colitis, Dr. Anna Malykhina and colleagues explored the effects of TRPV1 receptors in the colon on detrusor contractility.

Four groups of Sprague-Dawley rats were identified as follows:

* group 1: control (intracolonic saline);
* group 2: trinitrobenzene sulfonic acid (TNBS)-induced colitis;
* group 3: intracolonic resiniferatoxin (RTX); and
* group 4: intracolonic RTX and TNBS.

Bladder contractility was studied with cystometry at baseline and 3 days post-treatment as well as via measurement of detrusor contractility in isolated muscle strips in organ bath at 3 days post-treatment. Contractility was evaluated via electrical field stimulation (EFS), potassium chloride test , and carbachol dose response stimulation.

Acute colonic inflammation resulted in a significantly decreased detrusor contractility. Specifically, there was an almost 2-fold decrease in the response of the detrusor smooth muscle to EFS compared to the control group. The velocity of the response was also slower in the colitis group. Additionally, cystometry showed marked changes in bladder volume and detrusor pressure during micturition in animals with acute colitis.

The investigators concluded that acute inflammation in the distal colon modified the function of the urinary bladder via changes in detrusor muscle contractility.

Presented by Tirsit Asfaw, Joseph Hypolite, Gina Northington, Lyla Arya, Alan Wein, and Anna Malykhina at the American Urological Association (AUA) Annual Meeting - May 29 - June 3, 2010 - Moscone Center, San Francisco, CA USA

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This research shows that the genitorinary system can be affected by inflammation elsewhere in the pelvis.
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