NIH BIOMARKER/GENETIC STUDY

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Rufus
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NIH BIOMARKER/GENETIC STUDY

Post by Rufus »

NIH Seeks Biomarkers for Range of Internal Organ Diseases

June 05, 2009
By a GenomeWeb staff reporter

NEW YORK (GenomeWeb News) – The National Institutes of Health plans to fund studies aimed at validating genomic and other types of biomarkers for human diseases that affect the liver, kidney, urological tract, digestive and hematologic systems, and endocrine and metabolic disorders, according to a new funding announcement.

These studies also could pursue biomarkers that could be used in addressing diabetes and its complications, and obesity, for which there are few or no biomarkers, or those that are available are invasive or expensive.

Progress toward new biomarkers for these diseases could be used to advance translational research related to the efficacy of treatments and bio-behavioral interventions for a number of diseases, said NIH.

The "Development and Validation of Disease Biomarkers" grants, which will fund research for up to five years but does not set a limit on the funding levels researchers may seek, is funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute on Alcohol Abuse and Alcoholism, the National Institute of Nursing Research, and the Office of Dietary Supplements.

These studies could seek diagnostic or predictive markers for: interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome; development or progression of benign prostatic hyperplasia with lower urinary tract symptoms; and urologic disorders with overlapping symptoms.

The research also may seek various types of biomarkers for iron and copper accumulation; for disease activity for inflammatory diseases; gastrointestinal disorders; insulin resistance; angiogenesis; transplant rejection; and others
Age:37 | Onset Age: 35 | Symptoms: pain in testicles that comes and goes that also switches sides-trying to find a pattern as to "why" this happens/Rectal Burn at the 6 O'clock position at my anus which tends to flare around the periphery of my anus typically after defication but no perineum pain-no "golf ball" pain. Pain in testicles worsens as I sit but not always...Pain is not always present but depresses me. Pain used to be at a very high level but has subsided in time to a low level but has not gone away. Pain used to flare after sex but not as much as before although it still like playing russian roulette./
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
boulder
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Re: NIH BIOMARKER/GENETIC STUDY

Post by boulder »

Great find, Rufus! Nobody else has commented on this yet, but this seems like extremely good news, doesn't it?
Age: 36 | Onset Age: 29 (Summer 2005) Main Symptoms (all intermittent): penile/anal/rectal/perineum pain/numbness/tingling/coldness, LUTS, ED | Helped By: duloxetine (Cymbalta), topical benzocaine, occasional benzodiazepines, hot weather, hot baths, understanding friends & family, pushing myself to be more sociable and active, psychotherapy (mostly CBT), diaphragmatic breathing, relaxation, meditation (concentration and mindfulness), adequate sleep | Worsened By: cold weather, stress, inadequate sleep, prolonged sitting or standing in place, walking uphill, heavy exercise, erection/ejaculation (sometimes)
Last But Not Least: I am not a medical/health professional of any kind. This is not medical advice.
Rufus
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Re: NIH BIOMARKER/GENETIC STUDY

Post by Rufus »

Long time comin Boulder...Long time comin... :62_58_40:
Age:37 | Onset Age: 35 | Symptoms: pain in testicles that comes and goes that also switches sides-trying to find a pattern as to "why" this happens/Rectal Burn at the 6 O'clock position at my anus which tends to flare around the periphery of my anus typically after defication but no perineum pain-no "golf ball" pain. Pain in testicles worsens as I sit but not always...Pain is not always present but depresses me. Pain used to be at a very high level but has subsided in time to a low level but has not gone away. Pain used to flare after sex but not as much as before although it still like playing russian roulette./
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
Rufus
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Re: NIH BIOMARKER/GENETIC STUDY

Post by Rufus »

Uh...this is a bit strange...

Why is it NOBODY is commenting on this?
Age:37 | Onset Age: 35 | Symptoms: pain in testicles that comes and goes that also switches sides-trying to find a pattern as to "why" this happens/Rectal Burn at the 6 O'clock position at my anus which tends to flare around the periphery of my anus typically after defication but no perineum pain-no "golf ball" pain. Pain in testicles worsens as I sit but not always...Pain is not always present but depresses me. Pain used to be at a very high level but has subsided in time to a low level but has not gone away. Pain used to flare after sex but not as much as before although it still like playing russian roulette./
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
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Re: NIH BIOMARKER/GENETIC STUDY

Post by webslave »

We'll comment when and if there are findings. Putting aside some money to research something is not cause for comment, IMO.
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Rufus
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Re: NIH BIOMARKER/GENETIC STUDY

Post by Rufus »

Well for the NIH to do this type of research is astonishing to say the least, considering the type of research the NIH is prospectively doing ,the results could probably prove to be remarkable; specifically for men that do have a genetic or biological component to their pelvic pain and not a muscle related issue.
Age:37 | Onset Age: 35 | Symptoms: pain in testicles that comes and goes that also switches sides-trying to find a pattern as to "why" this happens/Rectal Burn at the 6 O'clock position at my anus which tends to flare around the periphery of my anus typically after defication but no perineum pain-no "golf ball" pain. Pain in testicles worsens as I sit but not always...Pain is not always present but depresses me. Pain used to be at a very high level but has subsided in time to a low level but has not gone away. Pain used to flare after sex but not as much as before although it still like playing russian roulette./
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
boulder
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Re: NIH BIOMARKER/GENETIC STUDY

Post by boulder »

I may have misunderstood what you were saying, Rufus, but I wanted to note that just because CPPS may have a hereditary/genetic component doesn't mean it isn't muscle related. A genetic predisposition could lead to neuromuscular pathology. And finding reliable biomarkers is important regardless. Research into biomarkers and genetics could be widely useful.
Age: 36 | Onset Age: 29 (Summer 2005) Main Symptoms (all intermittent): penile/anal/rectal/perineum pain/numbness/tingling/coldness, LUTS, ED | Helped By: duloxetine (Cymbalta), topical benzocaine, occasional benzodiazepines, hot weather, hot baths, understanding friends & family, pushing myself to be more sociable and active, psychotherapy (mostly CBT), diaphragmatic breathing, relaxation, meditation (concentration and mindfulness), adequate sleep | Worsened By: cold weather, stress, inadequate sleep, prolonged sitting or standing in place, walking uphill, heavy exercise, erection/ejaculation (sometimes)
Last But Not Least: I am not a medical/health professional of any kind. This is not medical advice.
boulder
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Re: NIH BIOMARKER/GENETIC STUDY

Post by boulder »

By the way, does anyone know if this is related to the NIH's Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP)? It appears to be separate, but I wonder... There would seem to be significant overlap in stated goals. Maybe there's a distinction I'm missing?
Age: 36 | Onset Age: 29 (Summer 2005) Main Symptoms (all intermittent): penile/anal/rectal/perineum pain/numbness/tingling/coldness, LUTS, ED | Helped By: duloxetine (Cymbalta), topical benzocaine, occasional benzodiazepines, hot weather, hot baths, understanding friends & family, pushing myself to be more sociable and active, psychotherapy (mostly CBT), diaphragmatic breathing, relaxation, meditation (concentration and mindfulness), adequate sleep | Worsened By: cold weather, stress, inadequate sleep, prolonged sitting or standing in place, walking uphill, heavy exercise, erection/ejaculation (sometimes)
Last But Not Least: I am not a medical/health professional of any kind. This is not medical advice.
Rufus
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Re: NIH BIOMARKER/GENETIC STUDY

Post by Rufus »

webslave wrote:We'll comment when and if there are findings. Putting aside some money to research something is not cause for comment, IMO.
So, you're saying that there is no reason to celebrate the NIH investing in trials and research?

I don't understand...

I would have thought this to be great news considering urologists and others in the medical profession, the majority at least simply throw up their hands write scripts for antidepressants, anti-inflammatory medicine and antibiotics and politely escort CPPS patients out the door...

Boulder-I never said this disease is not muscle related but there are people with CPPS in which physical therapy doesn't seem to work. They could be the minority but still deserve an end to their pain. Maybe this type of research could reveal a root cause that is not muscle relate and from this research offer some type of therapy or cure.

If you ask me this step on the part of the NIH is a cause for celebration. Rather have them on our side doing something rather than ignoring this disease/condition or whatever it is you 'd like to call it.
Age:37 | Onset Age: 35 | Symptoms: pain in testicles that comes and goes that also switches sides-trying to find a pattern as to "why" this happens/Rectal Burn at the 6 O'clock position at my anus which tends to flare around the periphery of my anus typically after defication but no perineum pain-no "golf ball" pain. Pain in testicles worsens as I sit but not always...Pain is not always present but depresses me. Pain used to be at a very high level but has subsided in time to a low level but has not gone away. Pain used to flare after sex but not as much as before although it still like playing russian roulette./
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
jVan
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Re: NIH BIOMARKER/GENETIC STUDY

Post by jVan »

How about a focused CPPS genetic study. There are plenty of volunteers here I'm sure. Any researchers who have even a small grant could do a very interesting phenotype vs protein (satellite microarray) study to get the ball rolling for a targeted genetic exploration. I wouldn't be surprised in the least if they found a common genotype at a signal locus. Then, who knows.

Any takers?

(If someone wants to post this idea elsewhere, do so please)
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