CNS is a key player in CPPS

Latest research and happenings
Post Reply
User avatar
webslave
Maintenance
Maintenance
Posts: 11390
Joined: Wed Oct 30, 2002 3:18 pm
Location: Please give your location so we can help better
Contact:

CNS is a key player in CPPS

Post by webslave »

Neuroimage Clin. 2017 Nov 15
Relationships between brain metabolite levels, functional connectivity, and negative mood in urologic chronic pelvic pain syndrome patients compared to controls: A MAPP research network study.

Until recently, the predominant pathology of chronic pelvic pain conditions was thought to reside in the peripheral tissues. However, mounting evidence from neuroimaging studies suggests an important role of the central nervous system in the pathogenesis of these conditions. .... abnormal GABA and choline levels in the brain of UCPPS patients compared to controls. Low GABA levels have been identified in other pain syndromes and might contribute to CNS hyper-excitability in these conditions.
Full article:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702874/

I have long believed that trigger points can be caused not only by psychological tension, but also by a direct and subconscious stimulation from the CNS. This is just a hunch at this stage, but results like the one above are suggestive.
HAS THIS SITE HELPED YOU?
Say Thanks! by making a small donation
PayPal link at end of page ↓
Please fill out your signature, click here for how to do it
User avatar
dshoskes
Urologist
Urologist
Posts: 204
Joined: Wed Oct 30, 2002 7:51 pm
Location: Cleveland Clinic, Ohio
Contact:

Re: CNS is a key player in CPPS

Post by dshoskes »

What is cause and what is effect? The achilles heal of these type of analyses.You could just as easily show that CPPS patients on average have higher tylenol levels in their blood than controls and say that it is the cause.
Daniel Shoskes MD
www.dshoskes.com
User avatar
webslave
Maintenance
Maintenance
Posts: 11390
Joined: Wed Oct 30, 2002 3:18 pm
Location: Please give your location so we can help better
Contact:

Re: CNS is a key player in CPPS

Post by webslave »

GABA levels are lower in brain of pts with chronic pain (also in fibromyalgia pts), but does pain lower GABA or does lower GABA cause pain? Chicken and egg. :confused:
HAS THIS SITE HELPED YOU?
Say Thanks! by making a small donation
PayPal link at end of page ↓
Please fill out your signature, click here for how to do it
Post Reply