Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Latest research and happenings
Post Reply
User avatar
webslave
Maintenance
Maintenance
Posts: 11390
Joined: Wed Oct 30, 2002 3:18 pm
Location: Please give your location so we can help better
Contact:

Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by webslave »

Brain Changes May Explain Chronic Pain Symptoms in Different Disorders, Study Suggests

https://fibromyalgianewstoday.com/2017/ ... disorders/
Even though fibromyalgia and urological chronic pelvic pain syndrome (UCPPS) are different disorders, new research suggests that patients suffering from these conditions may actually share alterations to the brain, perhaps explaining why certain UCPPS patients exhibit fibromyalgia characteristics, such as widespread pain.
HAS THIS SITE HELPED YOU?
Say Thanks! by making a small donation
PayPal link at end of page ↓
Please fill out your signature, click here for how to do it
Joe02324
New Member
New Member
Posts: 10
Joined: Tue May 23, 2017 4:45 am

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by Joe02324 »

Thanks for the article webslave-- coincidently I've had one doctor suggest a possible fibro diagnosis due to strange neuro pain and sx. I wonder if this means that CPPS sufferers might benefit from drugs that target the central nervous system in conjunction to PT/ psych therapy. Out of curiosity--I've read on a past thread that you used to experience a hand tremor when CPPS was at its worst--do you mind sharing what happened? When did it develop, how long did it last, how was it resolved, and any theories on how CPPS was related to that strange sx for you? Thanks appreciate all your work webslave!
Age 38 started experiencing frequent urination, frequent urge, weak urine stream, subtle pain in pelvic region. Had CT scan, 2 cystoscopies, ultra sound. Diagnosed with prostatitis by one urologist, narrow bladder neck by other urologist. SX made worse by ejaculation/constipation. Not sure what helps. Tried Bactrim, Levoquin - no help. Tried Flomax, Uroxatral, Rapiflow - no help. Sometimes experience high protein in urine, elevated mucous, bacteria in urine culture but docs dismiss the findings. Need help with diagnosis and possible solutions.
User avatar
webslave
Maintenance
Maintenance
Posts: 11390
Joined: Wed Oct 30, 2002 3:18 pm
Location: Please give your location so we can help better
Contact:

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by webslave »

It just resolved spontaneously, I don't know why. Was it quercetin?

The brain-CPPS link is fascinating. I proposed a central role many years ago. It seemed obvious to me. Now they are finding that there are brain changes in people with chronic pain conditions, but the question remains: cause or effect?

Quercetin also seems to have an effect on pain perception in the brain, namely quercetin alleviates generalized hyperalgesia.

As a urologist commented to me: a central role would explain why quercetin helps so many men.

And regarding quercetin: a problem I have had all my life is food sensitivity. Interestingly, I decided to start taking my any accredited quercetin product sample bottle (sent to me for photography by Supplier) before it expires. Had it lying around for a year or two. I noticed an immediate improvement in my IBS, allowing me to eat foods that normally cause diarrhea and tenesmus (cramping). I presume some effect on gut mast cells. I'd like to see Quercetin, and any accredited quercetin product in particular, trialled on people with IBS and/or food intolerance/food sensitivity reactions.
HAS THIS SITE HELPED YOU?
Say Thanks! by making a small donation
PayPal link at end of page ↓
Please fill out your signature, click here for how to do it
User avatar
webslave
Maintenance
Maintenance
Posts: 11390
Joined: Wed Oct 30, 2002 3:18 pm
Location: Please give your location so we can help better
Contact:

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by webslave »

Interesting new science on the brain and pain. The link below will play a podcast on the topic. Right click and "save as" to download.

How the brain shapes perceptions of pain (podcast mp3)
HAS THIS SITE HELPED YOU?
Say Thanks! by making a small donation
PayPal link at end of page ↓
Please fill out your signature, click here for how to do it
User avatar
HCR123
Intermediate Member
Intermediate Member
Posts: 70
Joined: Tue Jun 27, 2017 3:32 pm

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by HCR123 »

Excellent podcast. Really enjoyed that. I think it's very true in terms of how we react to pain and how we feel. I can tell you I can have the worst day because I'm thinking if the pain, then later in the day of I just ignore it or it feels slightly better, my brain reacts differently and I'm not irritated, depressed or anxious and that feeds the loop that's always discussed here. That helps break that loop. The more you can ignore the pain and get accustomed to it, the better off your nervous system will be.
Age: 43 | Onset Age: 43 | Symptoms: burning in tip of penis/urethra has mostly faded; mild pain in right testicle; main pain comes from anterior levator ani spasm | Helped By: hot baths, healing time days after PT, klonopin .25-.5mg, meditation (trying to learn) |Taking: 100mg zoloft (recent onset of tinnitus), Omega-3s, VSL3 Probiotic, Q-Rol, Zyflamend, Chelated Magnesium 500Mg | Worsened By: anxiety, depression, thinking about it too much | Other comments: sitting and pireneal and most penis pain/burning is gone from PT but just developed pain after ejaculation coming from levator; some pain from sitting too long depends on spasm; listening to Jon Kabat Zinn helps; need to de-stress my life; my PT says I'm at rock bottom and it's a long journey so I try to tell myself to be realistic about how long it will take and that this takes time so I try not to let it affect my social life
User avatar
webslave
Maintenance
Maintenance
Posts: 11390
Joined: Wed Oct 30, 2002 3:18 pm
Location: Please give your location so we can help better
Contact:

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by webslave »

Blood flow in the brain changes with treatment
https://pubmed.ncbi.nlm.nih.gov/28770549
HAS THIS SITE HELPED YOU?
Say Thanks! by making a small donation
PayPal link at end of page ↓
Please fill out your signature, click here for how to do it
User avatar
webslave
Maintenance
Maintenance
Posts: 11390
Joined: Wed Oct 30, 2002 3:18 pm
Location: Please give your location so we can help better
Contact:

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by webslave »

An impaired pain modulatory system in the brain, either by decreased descending pain inhibition or enhanced pain facilitation, may explain the pain symptoms in CP/CPPS:
https://pubmed.ncbi.nlm.nih.gov/28926645
HAS THIS SITE HELPED YOU?
Say Thanks! by making a small donation
PayPal link at end of page ↓
Please fill out your signature, click here for how to do it
User avatar
HCR123
Intermediate Member
Intermediate Member
Posts: 70
Joined: Tue Jun 27, 2017 3:32 pm

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by HCR123 »

Interesting stuff here webslave. So it just keeps reinforcing that the brain has a lot to do with CPPS. We can help ourselves by continuing to follow through with changes to our lifestyle to help reduce stress and incorporate meditation or activities that help distract.
Age: 43 | Onset Age: 43 | Symptoms: burning in tip of penis/urethra has mostly faded; mild pain in right testicle; main pain comes from anterior levator ani spasm | Helped By: hot baths, healing time days after PT, klonopin .25-.5mg, meditation (trying to learn) |Taking: 100mg zoloft (recent onset of tinnitus), Omega-3s, VSL3 Probiotic, Q-Rol, Zyflamend, Chelated Magnesium 500Mg | Worsened By: anxiety, depression, thinking about it too much | Other comments: sitting and pireneal and most penis pain/burning is gone from PT but just developed pain after ejaculation coming from levator; some pain from sitting too long depends on spasm; listening to Jon Kabat Zinn helps; need to de-stress my life; my PT says I'm at rock bottom and it's a long journey so I try to tell myself to be realistic about how long it will take and that this takes time so I try not to let it affect my social life
HateCPPS
Intermediate Member
Intermediate Member
Posts: 64
Joined: Tue Jan 10, 2017 11:23 pm

Re: Brain Changes May Explain Chronic Pain Symptoms in Different Disorders

Post by HateCPPS »

I have had two brain MRIs over about the last 2 years and had 6 very small 1-3mm unspecific white matter lesions. Not sure if they are at all related to CPPS. But after I got CPPS, sometime shortly I started to have consistent vertigo which doctors have dismissed as some sort of vestibular disorder. Really concerned that the the issue started after heavy nsaid use and PDE5 (viagra, cialis, staxyn) use. Whenever I used lots of nsaids or pde5s I started getting ringing in the ears and I feel they may have caused an issue.

Other than the CPPS and vertigo which started around similar times I have never had any other health issues in my life.
Age: 25 | Onset Age: 21 | Symptoms: Pain in perineum area, bad ED, slower stream, loss of libido, | Helped By: Uroxatral, Heavy Doses of NSAIDs, Really Hot Baths/Sauna | Worsened By: Sex, Masturbation, Spicy Foods, biking, certain exercises, sudafed| Other comments: Mine started in a time after copious amounts of sex, I also held in ejaculation for a long long time after a sex break which may have contributed. Also went from protected to unprotected sex around this same time, but all tests show no bacteria. I do not have urgency issues.
Post Reply