The Brain and CPPS

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webslave
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The Brain and CPPS

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Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study.

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a debilitating condition in which previous studies have revealed altered resting pelvic floor muscle activity in men with CP/CPPS compared to healthy controls. We hypothesized that the brain networks controlling pelvic floor muscles would also show altered resting state function in men with CP/CPPS. Here we describe the results of the first test of this hypothesis focusing on the motor cortical regions, termed pelvic-motor, that can directly activate pelvic floor muscles.

To our knowledge, this is the first report of abnormalities in resting state brain activity measures in men with CP/CPPS compared to healthy male controls

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MajorSky1
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Re: The Brain and CPPS

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So we have solid evidence that connectivity in the brain is altered in those with CPPS. Explains a lot about the sympathetic NS involvement too. Is the right-hand part a comparison for in Cortex connectivity? Or is it related to pelvic motor connectivity? Now if we could just figure out how to exercise the brain to get back to its normal connections in that spot. Fascinating read. Thanks for sharing.
Age: 49| Onset Age: 47| Symptoms: Pain locations: Intermittent left and right front pelvic floor lateral to urethra; occasionally left side tailbone pain (rarer); left spermatic chord pain (become rare); Post BM-Pain helped by distraction during Bowel Movement.| Current meds: None. Helped by: deep breathing, mediation, hiking, distractions, exercise. Approximately 98% improved, varying depending on stress levels.
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MajorSky1
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Re: The Brain and CPPS

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Been thinking about this report and had some other thoughts, questions. I'm just wondering, does "altered resting state" mean flipping the switch track in that part of the brain? Or is it more like a derailment, where it can't be switched back? Are they saying that the resting state of the pelvic-motor in people with CPPS is active in some way instead of in resting state? Have they determined anything more than that something is specifically different in people with CPPS? It begs the question as to what causes the change. Does the physical change in the resting state of the pelvic floor then change the pelvic-motor's resting state? Or vice versa? Or simultaneously? It seems like they are saying the pelvic-motor changing in this way is unique. That other motor regions do not, so much. No? Any sign of studies in the pipeline to answer more questions?
Age: 49| Onset Age: 47| Symptoms: Pain locations: Intermittent left and right front pelvic floor lateral to urethra; occasionally left side tailbone pain (rarer); left spermatic chord pain (become rare); Post BM-Pain helped by distraction during Bowel Movement.| Current meds: None. Helped by: deep breathing, mediation, hiking, distractions, exercise. Approximately 98% improved, varying depending on stress levels.
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Re: The Brain and CPPS

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It's a chicken and egg question. Are the brain changes because of the pain, or the pain because of the brain changes/abnormalities? Logic would suggest the former, but this is a new area of research so no solid answers are available. Key research will be to test whether the brain reverts to normal processing in men who recover from CPPS.
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