Recent Botox study

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gmccormack
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Recent Botox study

Post by gmccormack »

The trial was only 4 people so I would take resolution of symptoms for all patients involved with care...
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Botox as a Treatment for Chronic Male Pelvic Pain Syndrome
Information source: University of Washington
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Chronic Male Pelvic Pain Syndrome

Intervention: Botulinum Toxin A (Botox) (Drug)

Phase: Phase 4

Status: Terminated

Sponsored by: University of Washington

Official(s) and/or principal investigator(s):
Richard E Berger, MD, Principal Investigator, Affiliation: Professor of Urology

Summary
Chronic pelvic pain syndrome (CPPS) is thought to affect approximately 8% of men aged 18 and older. Patients with this condition experience pain in the perineum, the genitalia, and the rectum. As well, there is associated voiding, sexual, and ejaculatory dysfunction. The impact of patient well-being is thought to be equivalent to patients with congestive heart failure. The etiology of this condition is unknown, thus making treatment very difficult. Researchers have pursued an infectious cause for the disease; however, studies have failed to substantiate this theory. Despite this, the main treatment offered to patients is long-term antibiotic therapy. Results from this treatment modality have been unsatisfactory.

Other groups have postulated that the symptoms of CPPS may be secondary to neuromuscular factors. Some studies have demonstrated increases in pelvic muscular tone. Maneuvers such as prostate massage and levator massage have shown some benefit in relieving symptoms. Treatment with alpha-blockers to relax prostate smooth muscle has brought about improvement in a portion of patients. Use of generalized muscle relaxants has produced mediocre results.

However, many of these neuromuscular treatments are generalized and do not target the perineal musculature directly. It is theorized that spasm of the perineal muscles triggered by an unknown noxious stimuli (e. g. infection) cause the pain and symptoms of CPPS. At our center, we have performed pilot studies using botulinum toxin A. Four patients were treated with Botox". 100 U were injected in three locations in the midline of the bulbocavernosus muscle. The bulbocavernosus muscle is easily accessible and shares innervation with the pelvic musculature. Patient's response to medication was measured by the NIH Prostatitis pain scale and as well as the University of Washington prostatitis pain scale. All patients reported resolution of symptoms. Remission lasted for duration of 10-12 weeks. No patients reported adverse events.
HYPOTHESIS

Botulinum toxin A is effective in the treatment of chronic pelvic pain syndrome in men.
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h92
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Re: Recent Botox study

Post by h92 »

A stupid question : when they say "Remission lasted for duration of 10-12 weeks", do they mean that after this period symptoms were back or that they only looked for this long ?
Age: 31 Location: France Symptoms: right epididymis pain, testicular soreness and pain, pain after ejaculation, gulf ball in rectum (now gone), pain at tip of penis (now gone), bent penis when in pain (not Peyronie's), burning after ejaculation, weird right testicular positions, big and painful lymph nodes (now gone). Makes worse: sex, tiredness, anxiety, cold Makes better: hot climate, stretches.
gmccormack
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Re: Recent Botox study

Post by gmccormack »

I take it to mean symptoms returned, I think that's the downfall to using Botox. The symptoms return, but if you can continually get injections and shunt the pain cycle for months or years through a mechanisim like Botox maybe it will lead to remission WITHOUT anymore intervention. Here is the full study.
http://www.druglib.com/trial/23/NCT00194623.html

Although, 10-12 weeks doesnt seem that long, if it worked I think many men would use it and go repeatedly. It is widely used in woman after child birth, often times the muscle are in a spasm and Botox can resolve that. The use for CPPS is fairly new but not unheard of.
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