(Note: this is an abstract from a conference, not a published study.)
Clinical Impact Of Leukocytes In Chronic Abacterial Prostatitis
Authors: David T. Duong*, Rodney U Anderson, Stanford, CA
Introduction and Objective: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) accounts for up to 8% of male urology visits per year. NIH category III CP/CPPS includes painful nonbacterial prostatitis (IIIA, inflammatory) or prostatodynia (IIIB, non-inflammatory). Significant leukocytes from expressed prostatic secretion (EPS) or post-massage urine (VB3) implies inflammation. We evaluated the clinical relevance of leukocytes in refractory patients who failed multimodal therapy. Methods: One hundred fourteen patients came to Stanford for a week-long intensive course of pelvic myofascial trigger point physiotherapy and cognitive relaxation training. Patients completed two validated questionnaires: NIH chronic prostatitis symptom index (CPSI) and Stanford pelvic pain symptom survey (PPSS). Patients with positive cultures were excluded. Prostate massage EPS specimens with leukocyte counts ³5/hpf or 500/ul and ³5/hpf or 250/ul for VB3 were classified as inflammatory. Age, disease duration, symptom severity, and treatment efficacy were compared for IIIA and IIIB patients. Results: Median age 47 years; disease duration 8 years. Median pre-treatment CPSI and PPSS scores were 26 and 34, respectively. There were 44 category IIIA and 58 category IIIB patients. There was no significant difference between category IIIA and IIIB for either age (52 vs. 47 years; p=0.07) or disease duration (6 vs. 5 years; p=0.87). There was no significant difference between IIIA and IIIB in symptom severity for every domain of the CPSI (total score 26 vs. 26; p=0.36), except for quality of life (9 vs. 10; p=0.01). There was no significant difference between IIIA and IIIB in symptom severity for all domains of the PPSS (total score 34 vs. 34; p=0.87). Furthermore, there was no difference between IIIA and IIIB patients in symptomatic improvement after therapy: CPSI (-7 vs. -8; p=0.20) and PPSS (-10 vs. -10; p=0.68). Conclusions: Significant leukocytes in the EPS or VB3 of patients with refractory CPPS does not correlate with age, disease duration, or symptom severity. It also does not predict which patients will benefit from physiotherapy and cognitive behavior training. Determining the presence or absence of leukocytes from the prostate in uninfected CPPS patients does not appear to be clinically useful.
AUA 2009: Are Leukocytes important?
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AUA 2009: Are Leukocytes important?
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Re: AUA 2009: Are Leukocytes important?
This conclusion will always baffle me due to the fact my prostate at my onset was boggy and full of leukocytes and after that went down ( 10 days of mobic)...the discomfort did not stop...This condition is truly brilliant and clever like that....
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I encourage anxiety prone UCPPS people to consider L-Theanine
Age, 44 onset age 37 Feb 2006 Freq. need to urinate. Sensation of having to urinate soon after going. Perineum discomfort/burning/tightness, pubic area discomfort @ times,poor urine stream, post urine dripping/spray. All symptoms have improved with my protocol. At the worst I give it a 1 to 2 on irritation and discomfort and frequency. Helps: Elavil 5mg for anxiety and mast cell protection, (will only take it as needed) self internal PT as needed, stretching, walking, stairmaster cardio workout and light weights, reducing stress, moment to moment relaxation, deep breathing relaxation and using a Theracane. Makes worse: sitting for long periods, stress, over focusing on it. Currently 95%-98% recovered. Stay positive, relaxed and control your anxiety.
I encourage anxiety prone UCPPS people to consider L-Theanine
Age, 44 onset age 37 Feb 2006 Freq. need to urinate. Sensation of having to urinate soon after going. Perineum discomfort/burning/tightness, pubic area discomfort @ times,poor urine stream, post urine dripping/spray. All symptoms have improved with my protocol. At the worst I give it a 1 to 2 on irritation and discomfort and frequency. Helps: Elavil 5mg for anxiety and mast cell protection, (will only take it as needed) self internal PT as needed, stretching, walking, stairmaster cardio workout and light weights, reducing stress, moment to moment relaxation, deep breathing relaxation and using a Theracane. Makes worse: sitting for long periods, stress, over focusing on it. Currently 95%-98% recovered. Stay positive, relaxed and control your anxiety.
Re: AUA 2009: Are Leukocytes important?
I also had a very high level of WBC in my prostate fluid when this condition first set in.
Age:37 | Onset Age: 35 | Symptoms: pain in testicles that comes and goes that also switches sides-trying to find a pattern as to "why" this happens/Rectal Burn at the 6 O'clock position at my anus which tends to flare around the periphery of my anus typically after defication but no perineum pain-no "golf ball" pain. Pain in testicles worsens as I sit but not always...Pain is not always present but depresses me. Pain used to be at a very high level but has subsided in time to a low level but has not gone away. Pain used to flare after sex but not as much as before although it still like playing russian roulette./
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.