http://www.medicalnewstoday.com/medical ... wsid=60298Sensitization of Pelvic Nerve Afferents and Mast Cell Infiltration in the Urinary Bladder Following Chronic Colonic Irritation is Mediated by Neuropeptides
Written by Philip M. Hanno, MD
Thursday, 04 January 2007
BERKELEY, CA (UroToday.com) - Irritable bowel syndrome and interstitial cystitis frequently overlap.
Ustinova and colleagues from the University of Pittsburg have shown that acute colitis sensitizes urinary bladder afferents to both mechanical and chemical stimuli and that chronic colitis likewise produces neurogenic cystitis. Convergence of afferent pathways from the bladder and bowel is known to be a common feature of visceral interneurons which are thought to mediate vesico- and colono-sphincteric reflexes and colono-vesical corss-inhibitory interactions. Studies performed at the University of Pittsburg employing single unit C-fiber bladder afferent recording revealed that acute colonic irritation is capable of sensitizing urinary bladder afferents to mechanical and chemical stimuli, and interruption of the neural input to the bladder can ameliorate this effect, suggesting a direct afferent pathway from the colon.
The investigators hypothesized that chronic irritation of the colon releases neuropeptides from bladder afferent endings leading to receptor sensitization and neurogenic inflammation. They recorded single unit C-fiber bladder activity from fine filaments of the pelvic nerve in urethane-anesthetized Sprague-Dawley female rats and assessed their responsiveness to mechanical (bladder distention) and chemical (intravesical capsaicin, bradykinin, or substance P) stimulation 10 days following intracolonic administration of trinitrobenzenesulfonic acid (TNBS) or vehicle. To evaluate the role of C-fiber afferents and their associated neuropeptides, animals were pre-treated with capsaicin or vehicle 3 days prior to TNBS administration.
Chronic colonic irritation in the rat with TNBS sensitizes urinary bladder afferents to mechanical and chemical stimuli and induces bladder mastocytosis. A role of C-fiber afferents was further substantiated in this model of neurogenic cystitis as capsaicin pretreatment significantly ameliorated these effects. The authors experiments provide further support for neural processes in mediating cross-sensitization of pelvic organs and the overlap of PBS/IC, irritable bowel syndrome, and other chronic pelvic pain disorders.
Elena E Ustinova, Dmitriy W Gutkin, and Michael A Pezzone
American Journal of Physiology Renal Physiology (August 22, 2006)
Nerves, Mast Cells, Neuropeptides & Bladder Inflammation
Nerves, Mast Cells, Neuropeptides & Bladder Inflammation
Age:37 | Onset Age: 35 | Symptoms: pain in testicles that comes and goes that also switches sides-trying to find a pattern as to "why" this happens/Rectal Burn at the 6 O'clock position at my anus which tends to flare around the periphery of my anus typically after defication but no perineum pain-no "golf ball" pain. Pain in testicles worsens as I sit but not always...Pain is not always present but depresses me. Pain used to be at a very high level but has subsided in time to a low level but has not gone away. Pain used to flare after sex but not as much as before although it still like playing russian roulette./
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
/Lack of SleepHelped By: I haven't found anything that has helped to my knowledge. Tried many many sessions of PT, accupuncture and chiropractic care but still have not found steady relief that takes me back to a pre CPPS state.
- webslave
- Maintenance
- Posts: 11399
- Joined: Wed Oct 30, 2002 3:18 pm
- Location: Please give your location so we can help better
- Contact:
Aha! People, please all read this report. I believe it is an important study that shines a light on the true causes of most cases of chronic pelvic pain, prostatitis and interstitial cystitis, namely neurogenic inflammation via mast cell degranulation. This has been my contention for several years and underpins the definition of Pelvic Myoneuropathy. Read this for a fuller description of the interaction between nerves, muscles, bowels and LUTS.Chronic colonic irritation in the rat with TNBS sensitizes urinary bladder afferents to mechanical and chemical stimuli and induces bladder mastocytosis
The "chronic irritation of the colon" that "releases neuropeptides from bladder afferent endings leading to receptor sensitization and neurogenic inflammation" is equivalent to the same irritation and stimulation caused to the nervous plexus in the pelvis resulting from chronic muscle spasm / clenching / tensing.
HAS THIS SITE HELPED YOU? Say Thanks! by making a small donation PayPal link at end of page ↓ |