Page 1 of 1

MAPP research network update

Posted: Wed Aug 06, 2014 2:15 pm
by Wolfcub
The MAPP research network: design, patient characterization and operations
J Richard Landis, David A Williams, M Scott Lucia, Daniel J Clauw, Bruce D Naliboff, Nancy A Robinson, Adrie van Bokhoven, Siobhan Sutcliffe, Anthony J Schaeffer, Larissa V Rodriguez, Emeran A Mayer, H Henry Lai, John N Krieger, Karl J Kreder, Niloofar Afari, Gerald L Andriole, Catherine S Bradley, James W Griffith, David J Klumpp, Barry A Hong, Susan K Lutgendorf, Dedra Buchwald, Claire C Yang, Sean Mackey, Michel A Pontari, Philip Hanno, John W Kusek, Chris Mullins and J Quentin Clemens

BMC Urology 2014, 14:58 doi:10.1186/1471-2490-14-58

Published: 1 August 2014



The “Multidisciplinary Approach to the Study of Chronic Pelvic Pain” (MAPP) Research Network was established by the NIDDK to better understand the pathophysiology of urologic chronic pelvic pain syndromes (UCPPS), to inform future clinical trials and improve clinical care. The evolution, organization, and scientific scope of the MAPP Research Network, and the unique approach of the network’s central study and common data elements are described.


The primary scientific protocol for the Trans-MAPP Epidemiology / Phenotyping (EP) Study comprises a multi-site, longitudinal observational study, including bi-weekly internet-based symptom assessments, following a comprehensive in-clinic deep-phenotyping array of urological symptoms, non-urological symptoms and psychosocial factors to evaluate men and women with UCPPS. Healthy controls, matched on sex and age, as well as “positive” controls meeting the non-urologic associated syndromes (NUAS) criteria for one or more of the target conditions of Fibromyalgia (FM), Chronic Fatigue Syndrome (CFS) or Irritable Bowel Syndrome (IBS), were also evaluated. Additional, complementary studies addressing diverse hypotheses are integrated into the Trans-MAPP EP Study to provide a systemic characterization of study participants, including biomarker discovery studies of infectious agents, quantitative sensory testing, and structural and resting state neuroimaging and functional neurobiology studies. A highly novel effort to develop and assess clinically relevant animal models of UCPPS was also undertaken to allow improved translation between clinical and mechanistic studies. Recruitment into the central study occurred at six Discovery Sites in the United States, resulting in a total of 1,039 enrolled participants, exceeding the original targets. The biospecimen collection rate at baseline visits reached nearly 100%, and 279 participants underwent common neuroimaging through a standardized protocol. An extended follow-up study for 161 of the UCPPS participants is ongoing.


The MAPP Research Network represents a novel, comprehensive approach to the study of UCPPS, as well as other concomitant NUAS. Findings are expected to provide significant advances in understanding UCPPS pathophysiology that will ultimately inform future clinical trials and lead to improvements in patient care. Furthermore, the structure and methodologies developed by the MAPP Network provide the foundation upon which future studies of other urologic or non-urologic disorders can be based.

Trial registration identifier: NCT01098279 “Chronic Pelvic Pain Study of Individuals with Diagnoses or Symptoms of Interstitial Cystitis and/or Chronic Prostatitis (MAPP-EP)”.
Full Report: ... -14-58.pdf
MAPP Research Network Home Page:

Re: MAPP research network update

Posted: Wed Aug 06, 2014 2:25 pm
by Wolfcub
If you live in the U.S. you might want to participate in the ongoing research:

Contact: Nancy Robinson, PhD
Contact: Theressa Creighton, BA


University of Alabama at Birmingham Recruiting
Birmingham, Alabama, United States, 35205
Contact: Timothy J Ness
Principal Investigator: Timothy J Ness, MD, PhD

University of California, Los Angeles Recruiting
Los Angeles, California, United States, 90073
Contact: Suzanne Smith, NP 310-206-0310
Principal Investigator: Emeran A Mayer, MD
Principal Investigator: Larissa Rodriguez, MD
Stanford University Recruiting
Stanford, California, United States, 94304
Contact: Rachel Moericke 650-723-8250
Principal Investigator: Sean Mackey, MD, PhD

Northwestern University Recruiting
Chicago, Illinois, United States, 60611
Contact: Darlene Marko, RN, BSN, CCRC 312-695-3898
Principal Investigator: Anthony J Schaeffer, MD

University of Iowa Recruiting
Iowa City, Iowa, United States, 52242
Contact: Mary Eno, RN 319-384-9265
Principal Investigator: Karl J Kreder, MD, MBA

University of Michigan Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Megan Halvorson 734-998-6839
Contact: Kathy Scott, RN 734-998-7105
Principal Investigator: Daniel J Clauw, MD

Washington University Recruiting
St Louis, Missouri, United States, 63110
Contact: Viven Gardner, RN, BSN 314-996-8285
Principal Investigator: Gerald Adriole, MD

University of Washington Recruiting
Seattle, Washington, United States, 98101
Contact: Annemarie Succop 206-543-9731
Contact: Susan Ross, RN, MN 206-543-3898
Principal Investigator: Dedra Buchwald, MD