I am pleased to announce that we have a new NIH sponsored clinical trial for men and women with interstitial cystitis/painful bladder syndrome. The purpose is to study the effectiveness, side effects and mechanism of action of the oral drug cyclosporine in patients with IC/PBS who have failed at least 2 prior types of therapy and have persistent symptoms. It is an “open label” study and as such, all patients will receive the medication (at no charge). While Cyclosporine is not FDA approved for the treated of IC/PBS, it is a recommended option in the current treatment guidelines of the American Urological Association.
Patients: symptomatic IC/PBS who have failed at least 2 classes of treatment (eg. Elmiron and Elavil or Interstim and Physical Therapy). Exclusion criteria include kidney disease, current use of opiod narcotics, diabetes and cancer (there are others). A cystoscopy within the past year must show no other bladder pathology
Intervention: treatment for 3 months with Cyclosporine. Patients are allowed to stay on their current therapies as long as they are still sufficiently symptomatic while on them.
Testing: bloodwork, nuclear scan test of kidney function, urine tests and neurologic testing with a Neurometer device that measures skin sensation and pain perception. These tests are done before, during and after treatment with Cyclosporine.
This study is only being conducted at the main campus of the Cleveland Clinic in Cleveland Ohio
If interested, for more information please call 216-445-4757
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