Search found 326 matches

by J Dimitrakov
Sun Mar 29, 2009 9:22 pm
Forum: Research News & Updates
Topic: Adrenocortical Hormone Abnormalities in Men with CP/CPPS
Replies: 158
Views: 6437

Re: Adrenocortical Hormone Abnormalities in Men with CP/CPPS

Yes, it is possible to get tested. However, since this is (usually) non-classic CAH, testing is challenging and results, esp. negative results, need to be interpreted with caution or reconfirmed using a more sophisticated technique (e.g. genomic or proteomic technique)

best,
JD
by J Dimitrakov
Wed Mar 25, 2009 1:38 am
Forum: General Discussion
Topic: Mepartricin
Replies: 4
Views: 326

Re: Mepartricin

I am just wondering why no one is studying this in more detail. I searched the forum and though there have been questions raised on the study etc, no one has dismissed it. I got to know from a friend that a patient in italy emailed him and claimed to be cured from it. It's very difficult and almost...
by J Dimitrakov
Wed Mar 25, 2009 1:35 am
Forum: Research News & Updates
Topic: Adrenocortical Hormone Abnormalities in Men with CP/CPPS
Replies: 158
Views: 6437

Re: Adrenocortical Hormone Abnormalities in Men with CP/CPPS

I have waited to post this because I'm not sure if there is a connection? I have been off of Nasacort, a corticosteroid for more than a year now...and I have had the most significant recovery this past year out of the 3 plus years since my onset...Going back in my minds eye, my onset came a few yea...
by J Dimitrakov
Wed Mar 25, 2009 1:32 am
Forum: Research News & Updates
Topic: Adrenocortical Hormone Abnormalities in Men with CP/CPPS
Replies: 158
Views: 6437

Re: Adrenocortical Hormone Abnormalities in Men with CP/CPPS

S0b0T wrote: At this point its probably like trying to scavenge galaxies with binoculars.
It might actually be closer than you think. Technology is getting better now and gene sequencing, for example, which used to take several months, can now be done in a few days

Best,
JD
by J Dimitrakov
Wed Mar 25, 2009 1:29 am
Forum: Muscle Spasm & Anxiety Tx
Topic: Aromatase inhibitors and DIM / CHRYSIN
Replies: 10
Views: 294

Re: Aromatase inhibitors and DIM / CHRYSIN

Regarding tamoxifen use, I have been considering it after taking finasteride use, now even more after suffering twice from overtraining and damaging my HPA axis even more but since my cortisol reserve is not that high and I have some weird intracranial like headaches I am hesitant of trying it. Plu...
by J Dimitrakov
Wed Mar 25, 2009 1:26 am
Forum: Muscle Spasm & Anxiety Tx
Topic: Aromatase inhibitors and DIM / CHRYSIN
Replies: 10
Views: 294

Re: Aromatase inhibitors and DIM / CHRYSIN

Where can I get hold of this protocol doc? Plus I wanted to ask you to give me some insight about urology-neuroendocrinology books (if you know of any currently) regarding neuroendocrinological connections between the prostate the testicles and the penis mostly and less about the rest of the body (...
by J Dimitrakov
Tue Mar 24, 2009 1:37 am
Forum: Research News & Updates
Topic: Adrenocortical Hormone Abnormalities in Men with CP/CPPS
Replies: 158
Views: 6437

Re: Adrenocortical Hormone Abnormalities in Men with CP/CPPS

I think that we all agree with your statement that those are complex conditions and there is no one single approach that works for everyone. It will be an oversimplification to state that EVERYONE with CPPS has adrenocortical dysfunction, just as it would be incorrect to say they have CRH, pituitary...
by J Dimitrakov
Tue Mar 24, 2009 1:29 am
Forum: Muscle Spasm & Anxiety Tx
Topic: Aromatase inhibitors and DIM / CHRYSIN
Replies: 10
Views: 294

Re: Aromatase inhibitors and DIM / CHRYSIN

Anyone tried to tamper with their estrogen levels or making their estrogen metabolism more healthy by using DIM-indoplex or chrysin??? I am curious about results because i want to try this approach some day (along with using cortisol and testosterone) There is an ongoing clinical protocol for UCPPS...
by J Dimitrakov
Wed Mar 11, 2009 1:12 am
Forum: Research News & Updates
Topic: New genetics & UCPPS review by Dr. Dimitrakov
Replies: 9
Views: 307

Re: New genetics & UCPPS review by Dr. Dimitrakov

This is one of the most interesting articles I've read on CPPS in a while. It's my understanding that scientists have so far had more success in discovering genetic links to autoimmune conditions than to other types of diseases. For example, a lot of the conditions Navigenics tests for are autoimmu...
by J Dimitrakov
Sun Mar 01, 2009 10:57 pm
Forum: General Discussion
Topic: Etiology Question (cortisol)
Replies: 8
Views: 336

Re: Etiology Question (cortisol)

Hi, Jay, This is a plausible and testable hypotheses. However, there is another interesting fact: those same nicotinic neuromuscular junction receptors are blocked by tubocurarine (a classic muscle relaxant used for anesthesia). The same receptors in the autonomic nervous system (controlling smooth ...
by J Dimitrakov
Sun Mar 01, 2009 6:44 pm
Forum: General Discussion
Topic: Etiology Question (cortisol)
Replies: 8
Views: 336

Re: Etiology Question (cortisol)

I have chewed tobacco habitually for 5 years (mostly to stay up late and work), I noticed several months prior to the pain starting or my knowledge of CPPS when I placed the tobacco in my mouth my testicles would immediately pull up. I thought this was just some kind of psychological reaction of my...
by J Dimitrakov
Sun Mar 01, 2009 6:30 pm
Forum: Research News & Updates
Topic: Adrenocortical Hormone Abnormalities in Men with CP/CPPS
Replies: 158
Views: 6437

Re: Adrenocortical Hormone Abnormalities in Men with CP/CPPS

Hi, Kevin, Thanks for the interesting question. Cortisol is the predominant pacemaker of pain threshold setting. There are numerous intracellular pathways that are implicated in pain perception that are under glucocorticoid regulation, so any substance in the glucocorticoid pathway (the end product ...
by J Dimitrakov
Mon Feb 09, 2009 1:49 am
Forum: General Discussion
Topic: Advice on symptoms (TJ88 case)
Replies: 169
Views: 1303

Re: Prostatitis and low testosterone?

How much where your testosterone levels prior to taking this supplement?? Also state estradiol e2 and prolactin levels and any SHBG, albumin levels too. I am not sure if your question was addressed to me but I have seen one case similar to yours. I would suggest you consult an endocrinologist. The ...
by J Dimitrakov
Sat Feb 07, 2009 5:28 pm
Forum: Research News & Updates
Topic: Adrenocortical Hormone Abnormalities in Men with CP/CPPS
Replies: 158
Views: 6437

Re: Adrenocortical Hormone Abnormalities in Men with CP/CPPS

As part of our compliance with the NIH public access policy for NIH-funded research, the full-text of our article is now available for free download through PubMed Central.
http://www.pubmedcentral.nih.gov/articl ... d=18308097

Best,
JD